4/24/2023 0 Comments Agena bioscience![]() Conclusion: We found limited statistical evidence linking IFNG polymorphisms with a risk of developing iron deficiency and anaemia in Gambian children. A haplotype uniquely identified by IFNG+2200C was similarly associated with reduced haemoglobin levels and trends towards iron deficiency, anaemia and iron deficiency anaemia at the end of the malaria season in models adjusted for age, sex, village, inflammation and malaria parasitaemia. The IFNG+2200C allele was associated with reduced haemoglobin concentrations (adjusted β -0.44 Bonferroni adjusted P = 0.03) and a trend towards iron deficiency compared to wild-type at the end of the malaria season in multivariable models adjusted for potential confounders. Results: We identified five IFNG haplotype-tagging SNPs ( IFNG-1616, IFNG+874, IFNG+2200, IFNG+3234 and IFNG+5612 ). We also measured haemoglobin and biomarkers of iron status and inflammation at the start and end of a malaria season. Methods: We used previously available data from Gambian family trios to determine informative SNPs and then used the Agena Bioscience MassArray platform to type five SNPs from the IFNG gene in a cohort of 780 Gambian children aged 2-6 years. We investigated putative functional single nucleotide polymorphisms (SNPs) and haplotypes of IFNG in relation to nutritional iron status and anaemia in Gambian children over a malaria season. Genetic variants in the IFN-γ gene (IFNG) are associated with increased IFN-γ production. ![]() Interferon-gamma (IFN-γ) is elevated during malaria infection and is thought to influence erythropoiesis and iron status. Background: Anaemia is a major public health concern especially in African children living in malaria-endemic regions.
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